Franz meitinger dkfz. pdf (. Jul 1, 2012 · Summary. Affiliations. We show here that mitotic extension leads to the formation of p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 prot … Meitinger F et al. From midanaphase, the targeting function of Gin4 is taken over by the bud neck-associated protein Nba1. Franz Meitinger DKFZ-ZMBH-Alliance German Cancer Research Center Molecular Biology of Centrosomes and Cilia Im Neuenheimer Feld 581 69120 Heidelberg Phone: +49 6221 42 3453 Das Deutsche Krebsforschungszentrum hat die Aufgabe, die Mechanismen der Krebsentstehung systematisch zu erforschen und Risikofaktoren für Krebserkrankungen zu erfassen. jp; Karen Oegema, koegema@ucsd. , 2013, 2014). • Science • 29 Mar 2024 Mitosis is a challenging time for cells owing to the potential for structural and numerical chromosomal abnormalities, termed chromosomal instability, which is a hallmark of cancer ( 1 ). Here, we show that the MEN controls components involved in septum formation, including Inn1, Cyk3 and Chs2 Jun 1, 2010 · Franz Meitinger 1 , Boryana Petrova, Ilde Mancini Lombardi, Daniela Trinca Bertazzi, Birgit Hub, Hanswalter Zentgraf, Gislene Pereira Affiliation 1 German Cancer Research Centre, DKFZ-ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. Jul 18, 2016 · In normal human cells, centrosome loss induced by centrinone-a specific centrosome duplication inhibitor-leads to irreversible, p53-dependent G1 arrest by an unknown mechanism. S1 to S13 Tables S1 and S2 References Bahtiyar KURTULMUS | Cited by 354 | of German Cancer Research Center, Heidelberg (DKFZ) | Read 20 publications | Contact Bahtiyar KURTULMUS Franz Meitinger, Saravanan Palani and Gislene Pereira* German Cancer Research Center; DKFZ-ZMBH Alliance; Molecular Biology of Centrosomes and Cilia Unit; Heidelberg, Germany and cell cleavage (abscission). 53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration. Feb 26, 2019 · Meitinger, Franz and Pereira, Gislene, A Positive Feedback Mechanism Drives Membrane Ingression During Cytokinesis in an Actomyosin-Ring Independent Manner (January 16, 2019). Studying these cellular processes is the goal of Dr. PB - American Society for Cell Biology M1 - DKFZ-2017-01036 SP - 883 - 889 PY - 2017 AB - Cell cycle-dependent morphogenesis of unicellular organisms depends on the Jul 7, 2021 · Meitinger, Kong, Ohta, et al. Sc. edu; Arshad Desai, abdesai@ucsd. Franz Meitinger,1,5 Anton Khmelinskii,2 Sandrine Morlot,3 Bahtiyar Kurtulmus,1 Saravanan Palani,1,6 Amparo Andres-Pons, 1,7 Birgit Hub, 4 Michael Knop, 2 Gilles Charvin, 3 and Gislene Pereira 1, * 1 Molecular Biology of Centrosomes and Cilia, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, Franz Meitinger Position: Postdoctoral fellow. Cdc14 localizes at the site of cell cleavage after M-Cdk1 inactivation, suggesting that Cdc14 may perform a crucial, yet ill-defined, role May 1, 2013 · Franz Meitinger, a Saravanan Palani, a Birgit Hub, b and Gislene Pereira a, 1 Franz Meitinger a Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany Franz MEITINGER, PostDoc Position | Cited by 1,014 | of Ludwig Institute for Cancer Research, La Jolla | Read 29 publications | Contact Franz MEITINGER Research Interests Every day, millions of cells in our body divide to maintain essential tissue functions. in cell biology at the German Cancer Research Center in Heidelberg. 12 MB) Nov 20, 2014 · Authors. Davis, et al. Hof1 colocalizes at the cell division site with the septin complex and, as mitotic exit progresses, moves to the actomyosin ring (AMR). Gislene PEREIRA, Principal Investigator | Cited by 6,431 | of German Cancer Research Center, Heidelberg (DKFZ) | Read 128 publications | Contact Gislene PEREIRA. pereira{at}dkfz. Apr 1, 2017 · INTRODUCTION. The p53 circuit responds to a myriad of stress signals, including DNA damage, oncogene activation, metabolic fluctuations, and mitotic aberrations, and drives programs that can lead to temporary arrest, senescence, or cell death (Levine and Apr 15, 2011 · Franz Meitinger 1 , Martin E Boehm, Astrid Hofmann, Birgit Hub, Hanswalter Zentgraf, Wolf D Lehmann, Gislene Pereira Affiliation 1 Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany. ) University of Regensburg, Germany, 2007 Profile Franz Meitinger studied biology at the University of Regensburg and pursued a Ph. Sharrocks,2 and Gislene Pereira1,* 1Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany 2School of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK Summary Franz Meitinger. gps1∆ cells fail to suppress Cdc42 activation at the bud neck, resulting in the appearance of an additional collar around the bud neck that can be visualized Franz Meitinger et al. Franz Meitinger 1 2 , Saravanan Palani 3 , Gislene Pereira 4 (DKFZ), University of Heidelberg, Im Neuenheimer Feld 581, Heidelberg, 69120, Feb 27, 2013 · Franz Meitinger Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany Search for more papers by this author TY - JOUR AU - Meitinger, Franz AU - Pereira, Gislene TI - The septin-associated kinase Gin4 recruits Gps1 to the site of cell division. Aus den Ergebnissen dieser grundlegenden Arbeiten sollen neue Ansätze zur Vorbeugung, Diagnostik und Therapie entwickelt werden. Franz Meitinger 1 2 , Saravanan Palani 3 , Gislene Pereira 4 (DKFZ), University of Heidelberg, Im Neuenheimer Feld 581, Heidelberg, 69120, Feb 27, 2013 · Franz Meitinger, a Saravanan Palani, a Birgit Hub, b and Gislene Pereira a, 1 Franz Meitinger a Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany Assistant Professor interested in Cancer, Cell Proliferation, Genome Stability and Centrosomes · 職歴: Okinawa Institute of Science and Technology Graduate University (OIST) · 学歴: Heidelberg University · 場所: 恩納 · LinkedInのつながり214人。10億人のメンバーを擁するプロフェッショナルコミュニティであるLinkedInでFranz Meitingerさんの Franz Meitinger1, Heidi Richter2, Sabrina Heisel1, Birgit Hub3, Wolfgang Seufert2, Gislene Pereira1* 1Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany, 2Department of Genetics, University of Mar 28, 2024 · Prof. Affiliation: DKFZ-ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit 08/07 – 07/11 Jan 15, 2012 · Franz Meitinger 1 , Saravanan Palani, Gislene Pereira Affiliation 1 German Cancer Research Center, DKFZ-ZMBH Alliance, Molecular Biology of Centrosomes and Cilia Unit, Heidelberg, Germany. de; FAX 49-6221-423450. Conversely, the inhibition of Cdk1 activity after sister chromatid separation licenses cell divi-sion. Our research focuses on molecular mechanisms of cell division and quality control in normal and cancer cells in order to understand cell type-specific and tumor-suppressive mechanisms and to identify biomarkers that Apr 4, 2011 · Franz Meitinger, 1 Martin E. 201604081 (2016). com/abstract=3316805 or http://dx. During his doctoral work, he investigated the connection between cell division, polarity, and aging. , 2004; Barr and Gruneberg, 2007; Green et al. Small Molecule Discovery Program, Ludwig Institute for Cancer Research, La Jolla, CA, USA Franz Meitinger,1,5 Anton Khmelinskii,2 Sandrine Morlot,3 Bahtiyar Kurtulmus,1 Saravanan Palani,1,6 Amparo Andres-Pons, 1,7 Birgit Hub, 4 Michael Knop, 2 Gilles Charvin, 3 and Gislene Pereira 1, * 1 Molecular Biology of Centrosomes and Cilia, German Cancer Research Center (DKFZ), DKFZ-ZMBH Alliance, Im Neuenheimer Feld 581, Mar 29, 2024 · Mitotic duration is tightly constrained, and extended mitosis is characteristic of problematic cells prone to chromosome missegregation and genomic instability. show that loss of the ubiquitin ligase TRIM37 leads to the formation of ectopic condensates scaffolded by the centrosomal protein centrobin. 3316805. org/10. Feb 27, 2013 · Franz Meitinger, a Saravanan Palani, a Birgit Hub, b and Gislene Pereira a, 1 Franz Meitinger a Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany Franz Meitinger,1 Zoulfia Darieva,2 Astrid Hofmann,1,4 Andrew D. Molecular Biology of the Cell MBoC | ARTICLE Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis Franz Meitingera, Saravanan Palania, Birgit Hubb, and Gislene Pereiraa aMolecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, and bDepartment of Tumor Virology Franz Meitinger,1 Zoulfia Darieva,2 Astrid Hofmann,1,4 Andrew D. Boehm, 2 Astrid Hofmann, 1 Birgit Hub, 3 Hanswalter Zentgraf, 3 Wolf D. a Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, and b Department of T umor Virology, German . in the electron microscope facility of the DKFZ in Heidelberg. Specimen for electron microscopy were prepared by F. Available at SSRN: https://ssrn. Jul 5, 2021 · Franz Meitinger # 1 2 3 , Dong Kong # 4 , Midori Ohta # 1 2 3 , Arshad Desai # 1 2 3 , Karen Oegema # 1 2 3 , Jadranka Loncarek # 4 Affiliations 1 Ludwig Institute for Cancer Research, La Jolla, CA. Errors in cell division can lead to developmental disorders or cancer. (A) Schematic highlighting that prolonging mitosis beyond a threshold about three times longer than normal mitosis leads to G Jun 1, 2010 · Semantic Scholar profile for Franz Meitinger, with 103 highly influential citations and 30 scientific research papers. Molecular Biology of the Cell MBoC | ARTICLE Dual function of the NDR-kinase Dbf2 in the regulation of the F-BAR protein Hof1 during cytokinesis Franz Meitingera, Saravanan Palania, Birgit Hubb, and Gislene Pereiraa aMolecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, and bDepartment of Tumor Virology Mar 28, 2024 · By Franz Meitinger, Hazrat Belal, Robert L. Cytokinesis is the process that physically divides one cell into two at the end of mitosis. The tumor suppressor TP53, which encodes a transcription factor, is the most commonly mutated gene in cancer cells (Levine and Oren, 2009). Nov 16, 2022 · 2016; Lambrus et al. P was funded by Wellcome Trust (WT101885MA). Articles 1–20. ‪Assistant Professor, Okinawa Institute of Science and Technology‬ - ‪‪Cited by 1,427‬‬ - ‪Cell Cycle‬ - ‪Genome Stability‬ - ‪Cancer‬ - ‪Centrosomes‬. Franz Meitinger, head of the Cell Proliferation and Gene Editing Unit at the Okinawa Institute of Science and Technology (OIST), Dr. jp Pubmed | Google Scholar | ORCID Professional Experience since 2022 Assistant Professor at Okinawa Institute for Science and Technology, Okinawa, Japan 2017. in the lab of Gislene Pereira at the DKFZ in Heidelberg, Germany. It also pre-vents Cdc42 activation at the bud neck and so ensures that cells always select a new bud site for each division (Meitinger et al. Corresponding authors: Franz Meitinger, franz. Boehm,2 Astrid Hofmann,1 Birgit Hub,3 Hanswalter Zentgraf,3 Wolf D. Our data show that Gps1 is targeted to the cell division site in a biphasic manner, via Gin4 and Nba1, to control the spatiotemporal activation of Rho1 and inhibition of Cdc42. 1126/science. Supplemental Information Download . Sharrocks,2 and Gislene Pereira1,* 1Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany 2School of Life Sciences, University of Manchester, Oxford Road, Manchester M13 9PT, UK Summary Sep 9, 2020 · Franz Meitinger, Midori Ohta, Kian-Yong Lee, Sadanori Watanabe, Ruth Kabeche, Arshad Desai & Karen Oegema. A genome-wide CRISPR/Cas9 screen for centrinone resistance identified genes encoding the p53-binding protein 53BP1, the deu … Jul 7, 2016 · Introduction. 1. As daughter cell arrest is independent of the cause of the extended mitotic duration (Uetake and Sluder, 2010), the monitoring mechanism Feb 27, 2013 · Franz Meitinger a, Saravanan Palani a, Birgit Hub b, and Gislene Pereira a. Condensates nucleate microtubules in mitosis, elevating the frequency of multipolar Sep 23, 2013 · Ilde Mancini Lombardi 1 , Saravanan Palani, Franz Meitinger, Zoulfia Darieva, Astrid Hofmann, Andrew D Sharrocks, Gislene Pereira Affiliation 1 Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 581, 69120 Heidelberg, Germany. [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Fig. Feb 26, 2013 · Franz Meitinger, Affiliation Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany ⨯ . Among its cytokinesis-related substrates is the F-BAR protein Hof1. Franz Meitinger. Franz Meitinger; Heidi Richter Franz Meitinger 1 , Midori Ohta 2 , Kian-Yong Lee 2 , Sadanori Watanabe 2 , Robert L Davis 3 , John V Anzola 3 , Ruth Kabeche 2 , David A Jenkins 3 , Andrew K Shiau 3 4 , Arshad Desai # 5 6 7 , Karen Oegema # 8 9 10 ORCID record for Franz Meitinger. The process in which cells divide is complex and things can go wrong at any stage causing severe diseases, including cancer. 1083/jcb. Neither the … Feb 26, 2013 · Franz Meitinger, 1 Heidi Richter, 2 Sabrina Heisel, 1 Birgit Hub, 3 Wolfgang Seufert, 2 and Gislene Pereira 1 , * Franz Meitinger 1 Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany Jun 1, 2010 · The mitotic-exit network (MEN) is a signaling pathway that is essential for the coordination of mitotic exit and cytokinesis. edu Science 383, 1441 (2024) DOI: 10. Franz Meitinger Okinawa Institute for Science and Technology 1919-1 Tancha, Onna, Kunigami District, Okinawa 904-0495 franz. , 2012; Wloka and Bi, 2012; Meitinger and Palani, 2016). meitinger@oist. , 2016)). In Saccharomyces cerevisiae the Cdc14 phosphatase plays a well-established role in reverting phosphorylation events on substrates of the mitotic cyclin-dependent kinase (M-Cdk1), thereby promoting mitotic exit and downregulation of M-Cdk1 activity. ) University of Regensburg, Germany, 2007; Franz Meitinger studied biology at the University of Regensburg and pursued a Ph. (A) Schematic highlighting that prolonging mitosis beyond a threshold about three times longer than normal mitosis leads to G Franz Meitinger1, Heidi Richter2, Sabrina Heisel1, Birgit Hub3, Wolfgang Seufert2, Gislene Pereira1* 1Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany, 2Department of Genetics, University of Franz Meitinger 1 , 2 , Saravanan Palani 3 , Gislene Pereira 1 Franz Meitinger 1 DKFZ-ZMBH Alliance, German Cancer Research Center (DKFZ), University of Cell Proliferation and Gene Editing Unit (Franz Meitinger) Cell Signal Unit (Tadashi Yamamoto) Chemistry and Chemical Bioengineering Unit (Fujie Tanaka) Cognitive Neurorobotics Research Unit (Jun Tani) Complex Fluids and Flows Unit (Marco Edoardo Rosti) Complexity Science and Evolution Unit (Ulf Dieckmann) Computational Neuroethology Unit (Sam The human body consists of millions of cells, many of them dividing every day to keep our tissues healthy and functional. Meitinger, Franz; Pereira, Gislene Apr 15, 2011 · Franz Meitinger 1 , Martin E Boehm, Astrid Hofmann, Birgit Hub, Hanswalter Zentgraf, Wolf D Lehmann, Gislene Pereira Affiliation 1 Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany. Mar 29, 2024 · Fig. doi. Control of G 1 progression and cell proliferation by memories of mitosis. Lehmann, 2 and Gislene Pereira 1, 4 Franz Meitinger 1 Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Germany; The conserved NDR-kinase Dbf2 plays a critical role in cytokinesis in budding yeast. Hazrat Belal, a researcher at the unit, and their Franz Meitinger 1, Martin E. Boehm 2, Astrid Hofmann 1, Birgit Hub 3 E-MAIL g. D. Whereas the role of the MEN in mitotic exit is well established, the molecular mechanisms by which MEN components regulate cytokinesis remain poorly understood. JO - Molecular biology of the cell VL - 28 IS - 7 SN - 1939-4586 CY - Bethesda, Md. Meitinger etal. J Cell Biol 214 , 155–166, doi: 10. 1290 F. ORCID provides an identifier for individuals to use with their name as they engage in research, scholarship, and innovation activities. 2139/ssrn. Lehmann, 2 and Gislene Pereira 1,4 1 Molecular Biology of Centrosomes and Cilia Unit, DKFZ-ZMBH Alliance, German Cancer Research Center, 69120 Heidelberg, Jan 13, 2016 · Electron micrographs of budding yeast cells were taken by F. Franz Meitinger 1 , Anton Khmelinskii 2 , Sandrine Morlot 3 , Bahtiyar Kurtulmus 1 , Saravanan Palani 1 , Amparo Andres-Pons 1 , Birgit Hub 4 , Michael Knop 2 , Gilles Charvin 3 , Gislene Pereira 5. add9528 The PDF file includes: Materials and Methods Figs. M. S. In budding yeast, the mitotic exit. Meitinger | et al. Assistant Professor; PhD University of Heidelberg, Germany, 2011; Diplom (M. , 2016; Meitinger et al. This project was funded by the Marie Curie Grant MEXT-CT-042544 and DKFZ core funding. Apr 1, 2011 · Europe PMC is an archive of life sciences journal literature. Franz Meitinger,1 Martin E. Franz Meitinger Assistant Professor PhD University of Heidelberg, Germany, 2011 Diplom (M. In animal and yeast cells, a contractile actomyosin ring drives plasma membrane ingression to execute cytokinesis (Balasubramanian et al. jejn yxhmzb ctjzv qlj yecs jsmrl acyhmst zhi byum tcoozq